Behavioral and neurochemical changes induced by post-weaning female rats isolation

Rodents post-weaning isolation could be considered a significant early-life model of chronic stress. The aim our study was to investigate the effects female rats on different behavioral tests and neurochemical parameters. On postnatal day 21, pups were housed either isolated or socially in groups (4/cage) for 6 weeks. After 6th week adult behaviorally examined using open field test, three chamber social interaction hole board test condition avoidance test. In addition, hippocampal content neurotransmitters, oxidative stress inflammatory markers measured. Isolated exhibited changes, shows increase anxiety decrease locomotor activity comparison control group . Moreover, promoted sociality index as compared groups. Finally, invoked impairment long-term short-term memory evaluated by both conditioned tests, group. Furthermore, post- weaning induced stress, inflammation, neurotransmitter alterations. Collectively post had significantly prompted changes which represent essential important symptoms schizophrenia.